… P values, increasing proportions will be detected at increasingly liberal significance thresholds
(P T ), for example, P T < 0.1 or P T … alleles at different association test P T thresholds. For …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

… p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024),
and educational attainment (p=0·… disease risk showed a robust association (p=8·00 × 10 −7 ). …

… mutations had more than expected direct interconnections (P = 0.008), which was consistent
with more overall connectivity to synaptic proteins as a whole (P = 0.005). b, Overlap of …

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

… Thus, our primary analysis is based on unadjusted P … of P < 1 × 10 −5 and P < 5 × 10 −7
as moderately strong and strong evidence for association, respectively 4 . Loci (n = 12) with P < …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…

… In the resulting data, gene-wide P values were calculated by combining the P values of all …
Next, we calculated competitive gene set P values on the gene-wide P values after accounting …