… p 001 =1−(1−Se 1 )(1−Se 2 )−γ Se , and the specificity is p 000 =Sp 1 Sp 2 +γ Sp . For a
serial-interpretation scheme, the sensitivity is p 111 =Se 1 Se 2 +γ Se , and the specificity is 1−p …

Objective Because differentiated (follicular and papillary) thyroid cancer (DTC) may recur
years after initial treatment, the follow-up of patients with DTC is long term. However, this …

Epidemiology of thyroid diseases in iodine-sufficient areas (ISA) deals with sporadic goiter,
thyroid autoimmune diseases, and thyroid cancer. A comparison between the different …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Background The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care
based on similar survival to and less toxicity than adjuvant 5-fluorouracil/folinic acid in patients …

Context Adjuvant fluorouracil has been shown to be of benefit for patients with resected
pancreatic cancer. Gemcitabine is known to be the most effective agent in advanced disease as …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …