Heterotaxy (also known as situs ambiguous) and situs inversus totalis describe disorders of
laterality in which internal organs do not display their typical pattern of asymmetry. First …

Generation of laterality depends on a pathway which involves the asymmetrically expressed
genes nodal, Ebaf, Leftb, and Pitx2[1–3]. In mouse, node monocilia are required upstream …

Purpose and objective Bone resection regarding adequate surgical margins is the treatment
of choice for malignant bone tumors. In the case of metastasis-related complications, so-…

Unidirectional fluid flow plays an essential role in the breaking of left-right (LR) symmetry in
mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We …

DYX1C1 has been associated with dyslexia and neuronal migration in the developing
neocortex. Unexpectedly, we found that deleting exons 2–4 of Dyx1c1 in mice caused a …

Primary ciliary dyskinesia (PCD) is characterized by dysfunction of respiratory cilia and
sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 …

… in patients without mutations compared with patients with genetic disease (P = 0.02) (Figure
3). … a mutation in podocyte genes show a slower progression to ESRD over time (P = 0.02). …

… and ZMYND10, we found that the five truncating protein alterations (p.Gln188*, … and p.Thr237Lysfs*7)
abrogated interaction with DVL3 but that the most distal truncating alteration (p.…

… 716A>G, p.His239Arg) affecting a highly conserved amino acid residue in one individual (…
The P value shown is based on a two-paired t-test. Error bars in c and f are the sd …

A diverse family of cytoskeletal dynein motors powers various cellular transport systems,
including axonemal dyneins generating the force for ciliary and flagellar beating essential to …