T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and
drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this …

… 8, there was a significant correlation between the day-of-challenge NtAb titers against the
challenge virus and the reduction of viral load (P ≤ 0.005 and 0.010 for peak and setpoint viral …

Despite the enormous effort in the development of effective vaccines against HIV-1, no
vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation of …

Despite continued progress in the development of novel antiretroviral therapies, it has become
increasingly evident that drug-based treatments will not lead to a functional or sterilizing …

We investigated the role of blood dendritic cells (DCs) in transmission of HIV-1 from infected
to uninfected CD4+ T cells, and the accessory molecules involved. DCs promoted …

… Significant differences determined by ANOVA with a #p value < 0.05. Dunnett’s post hoc
analyses were performed comparing post-SIV time points to baseline with an adjusted *…

We have focused on gene therapy approaches to induce functional cure/remission of HIV-1
infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral …

… Following autologous transplantation, tissue-associated SHIV DNA and RNA levels in
suppressed animals are significantly reduced (p ≤ 0.05), relative to suppressed, untransplanted …

We evaluated four priming-boosting vaccine regimens for the highly pathogenic simian human
immunodeficiency virus SHIV89.6P in Macaca nemestrina. Each regimen included gene …

Methods: Peripheral blood mononuclear cells (PBMC) from macaques inoculated intrarectally
with various dilutions of SIV were examined for their in vitro proliferative response to SIV …