Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …

… in our scRNAseq dataset (y-axis) (P < 0.05 using two-sided Wilcoxon rank-… (P < 0.05 using
two-sided Wilcoxon rank-sum test with Bonferroni correction. G Plot of negative log adjusted P-…

… where p mn is constrained to be a probability distribution for each cell: p m n ≥ 0 and ∑
n p m n = 1 ⁠. This construction ensures the rates are set such that the expected number of …

… 2.4-fold enriched at the random GWAS loci ( P = 0.005). We then used SNPsnap to retrieve
… From this we calculated an empirical P- value showing no enrichment of synapse genes ( P …

We conduct a large-scale genetic association analysis of educational attainment in a sample
of~ 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. …

… Relative expression was calculated using the formula: Re l a t i v e e x p r e s s i o n = 2 −
( C q T a r g e t − C q R e f ) × C where CqTarget = the quantification cycle (Cq) for the target …

Adipocyte function is a major determinant of metabolic disease, warranting investigations of
regulating mechanisms. We show at single-cell resolution that progenitor cells from four …