The genomes of all organisms throughout the tree of life are compacted and organized in
chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which …

… To address this question, van der Valk et al. used biochemical techniques to study the activity
of H-NS from E. coli under different environmental conditions. The experiments show that …

… These experiments were performed as previously described (RA van der Valk, et al.,
submitted for publication in Methods in Molecular Biology and Ref. 39) with some minor …

… The association of Hha with H-NS enhances its ability to bridge DNA and form loops [van
der Valk et al., unpubl. results], suggesting a possible mechanism by which Hha affects gene …

Many archaea express histones, which organize the genome and play a key role in gene
regulation. The structure and function of archaeal histone–DNA complexes remain however …

In archaea, histones play a role in genome compaction and are involved in transcription
regulation. Whereas archaeal histones bind DNA without sequence specificity, they bind …

The PainDETECT questionnaire (PD-Q), originally developed and validated in a multicentre
study of neuropathic pain (NeP) patients with back pain, is increasingly being applied to …

Architectural DNA binding proteins are key to the organization and compaction of genomic
DNA inside cells. Tethered Particle Motion (TPM) permits analysis of DNA conformation and …

Architectural DNA-binding proteins are key to the organization and compaction of genomic
DNA inside cells. The activity of architectural proteins is often subject to further modulation …

Sso10a proteins are small DNA-binding proteins expressed by the crenarchaeal model
organism Sulfolobus solfataricus. Based on the structure of Sso10a1, which contains a winged …