Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome 1
, 2 , 3 yet their potential involvement in human disease is not well understood 4 , 5 . Recent …

Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …

Cancer invasion and metastasis have been likened to wound healing gone awry. Despite
parallels in cellular behavior between cancer progression and wound healing, the molecular …

Radiologic screening of high-risk adults reduces lung-cancer-related mortality 1 , 2 ; however,
a small minority of eligible individuals undergo such screening in the United States 3 , 4 . …

High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate
personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood and …

We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs)
using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-…

The morphological interpretation of histologic sections forms the basis of diagnosis and
prognostication for cancer. In the diagnosis of carcinomas, pathologists perform a …

Identifying molecular residual disease (MRD) after treatment of localized lung cancer could
facilitate early intervention and personalization of adjuvant therapies. Here, we apply cancer …

… TO Nielsen, RB West, and SC Linn contributed equally to this project with tissue selection,
study design, and data analysis. O Alter did singular value decomposition analysis. MA …

Gastrointestinal stromal tumors (GIST) occur primarily in the wall of the intestine and are
characterized by activating mutations in the receptor tyrosine kinases genes KIT or PDGFRA. …