Gene expression occurs either as an episodic process, characterized by pulsatile bursts, or
as a constitutive process, characterized by a Poisson-like accumulation of gene products. It …

Recent work demonstrates that stochastic fluctuations in molecular populations have
consequences for gene regulation 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 . Previous experiments focused on …

Remarkable progress in bioengineering over the past two decades has enabled the formulation
of fundamental design principles for a variety of medical and non-medical applications. …

The therapeutic potential of pharmacologic inhibition of bromodomain and extraterminal (BET)
proteins has recently emerged in hematological malignancies and chronic inflammation. …

Steady-state behavior and bistability have been proposed as mechanisms for decision making
in gene circuits 1 , 2 , 3 . However, transient gene expression has also been proposed to …

Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification.
We used such fluctuations to modulate reactivation of HIV from latency—a quiescent state …

… Along these lines, Weinberger, Dar, and Simpson used measured noise correlation shifts
in HIV-1 transactivation circuits in human immune cells (Jurkat) to determine the strength of …

Recent technological breakthroughs in our ability to derive and differentiate induced
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …

Within individual cells, two molecular processes have been implicated as sources of noise
in gene expression: (i) Poisson fluctuations in mRNA abundance arising from random birth …

Diverse biological systems utilize fluctuations ("noise") in gene expression to drive lineage-commitment
decisions. However, once a commitment is made, noise becomes detrimental to …