User profiles for R. H. Duerr
 | Richard DuerrProfessor of Medicine, University of Pittsburgh Verified email at pitt.edu Cited by 41389 |
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
…, H Britton, T Moran, R Karaliuskas, RH Duerr… - Nature, 2001 - nature.com
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is
thought to result from the effect of environmental factors in a genetically predisposed host. A …
thought to result from the effect of environmental factors in a genetically predisposed host. A …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …
studies. To advance gene discovery further, we combined data from three studies on …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease. …
replication studies that identify several new regions of association to Crohn disease. …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
Following recent success in genome-wide association studies, a critical focus of human genetics
is to understand how genetic variation at implicated loci influences cellular and disease …
is to understand how genetic variation at implicated loci influences cellular and disease …