… Schornack, PA & Gillies, RJ Contributions of cell metabolism and H + diffusion to the acidic
pH of tumors. Neoplasia (New York) 5, 135–145 (2003). Determined proton production rates …

… each pair of 20 independent computer-generated segmentations of individual lung tumors
and report the average SI for each lesion, calculated using following equation:(2) A v e r a g e …

… Gillies reports stock options from HealthMyne Inc and grants and personal fees from Helix
Biopharma, all outside the submitted work. Udo Hoffmann reports institutional research grants …

Human cancers exhibit strong phenotypic differences that can be visualized noninvasively
by medical imaging. Radiomics refers to the comprehensive quantification of tumour …

Background Radiomic features may quantify characteristics present in medical imaging.
However, the lack of standardized definitions and validated reference values have hampered …

… generating correlation coefficients (R 2 ). Individual features were then clustered and plotted
along both axes, and R 2 is shown as a heat map, with areas of high correlation (R 2 > 0.95) …

… where R is the ratio of emissions from the 2 channels, R A is the maximal ratio (observed
at acidic endpoint); R B is the minimal ratio (observed at the alkaline endpoint), and [(F B(λ2))/(…

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

… In vitro spheroid doubling times are between 1 and 4 days, therefore, we take r 2 = ln 2/2.5 …
E, we see that r 3 ≈ d 3 (H core − H 0 ) / K 2 . Assuming a core pH of 6.4, we get r 3 ≈ 2.2 × …

… Four combinations of mixed cell populations that include FR with high free-field fitness and
high sensitivity to therapy, and R with lower fitness and low sensitivity to therapy, S with low …