Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are present
in almost all eukaryotic organisms, including humans. They are the key energy suppliers …

Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic
features such as a compact circular genome. Consequently, in mammals, mitochondrial DNA is …

Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome (mtDNA) …

The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and
turnover. It consists of a nine‐subunit catalytically inert core that serves a structural function …

Accurate tRNA processing is crucial for human mitochondrial genome expression, but the
mechanisms of mt-tRNA cleavage and the key enzymes involved in this process are poorly …

RNA decay is usually mediated by protein complexes and can occur in specific foci such as
P-bodies in the cytoplasm of eukaryotes. In human mitochondria nothing is known about the …

The mechanism of human mitochondrial RNA turnover and surveillance is still a matter of
debate. We have obtained a cellular model for studying the role of hSuv3p helicase in human …

Expression of mitochondrially encoded genes must be finely tuned according to the cell's
requirements. Since yeast and human mitochondria have limited possibilities to regulate gene …

MGME1, also known as Ddk1 or C20orf72, is a mitochondrial exonuclease found to be
involved in the processing of mitochondrial DNA (mtDNA) during replication. Here, we present …

hDIS3 is a mainly nuclear, catalytic subunit of the human exosome complex, containing
exonucleolytic (RNB) and endonucleolytic (PIN) active domains. Mutations in hDIS3 have been …