By combining an inducible genetic fate mapping strategy with electrophysiological analysis,
we have systematically characterized the populations of cortical GABAergic interneurons …

Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal.
However, the rising incidence of obesity, which results in chronically elevated insulin levels, …

… Those that develop lose their intermediate identity, as evidenced by the loss of Eve, a marker
for the RP-2 neuron population normally found in this domain, and are respecified to either …

Sensory perception depends on neocortical computations that contextually adjust sensory
signals in different internal and environmental contexts. Neocortical layer 1 (L1) is the main …

Neurogliaform (RELN+) and bipolar (VIP+) GABAergic interneurons of the mammalian cerebral
cortex provide critical inhibition locally within the superficial layers. While these subtypes …

The existence of stem cells in the adult nervous system is well recognized;however, the
potential of these cells is still widely debated. We demonstrate that neural stem cells exist within …

Dopamine transmission is critical for exploratory motor behaviour. A key regulator is
acetylcholine; forebrain acetylcholine regulates striatal dopamine release, whereas brainstem …

Abnormalities in GABAergic inhibitory circuits have been implicated in the aetiology of autism
spectrum disorder (ASD). ASD is caused by genetic and environmental factors. Several …

Human cytomegalovirus downregulates the expression of human class I major histocompatibility
complex (MHC) molecules by accelerating destruction of newly synthesized class I …

Background During the embryonic development of the cerebellum, neurons are produced
from progenitor cells located along a ventricular zone within dorsal rhombomere 1 that …