The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

…, SB Flohé, WJ Wiersinga, R Almansa… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Current gaps in sepsis immunology: new opportunities for translational research

…, M Martin-Fernandez, R Almansa… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group …

COVID-19 as a cardiovascular disease: the potential role of chronic endothelial dysfunction

JF Bermejo-Martin, R Almansa, A Torres… - Cardiovascular …, 2020 - academic.oup.com
As the SARS-CoV-2 pandemics evolves, there is mounting evidence that the cardiovascular
system plays a role in the pathophysiology of COVID-19 disease. In their interesting recent …

[HTML][HTML] Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza

…, R Ortiz de Lejarazu, T Pumarola, J Rello, R Almansa… - Critical care, 2009 - Springer
Introduction Human host immune response following infection with the new variant of A/H1N1
pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic …

[HTML][HTML] Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

JF Bermejo-Martin, M González-Rivera, R Almansa… - Critical Care, 2020 - Springer
Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2
RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-…

Unsupervised analysis of transcriptomics in bacterial sepsis across multiple datasets reveals three robust clusters

…, R Henao, JF Bermejo-Martin, R Almansa… - Critical care …, 2018 - journals.lww.com
Objectives: To find and validate generalizable sepsis subtypes using data-driven clustering.
Design: We used advanced informatics techniques to pool data from 14 bacterial sepsis …

A combined score of pro-and anti-inflammatory interleukins improves mortality prediction in severe sepsis

D Andaluz-Ojeda, F Bobillo, V Iglesias, R Almansa… - Cytokine, 2012 - Elsevier
Identification of patients at increased risk of death is dramatically important in severe sepsis.
Cytokines have been widely assessed as potential biomarkers in this disease, but none of …

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

…, J González, G Torres, M Bernal, S Pico, R Almansa… - Translational …, 2021 - Elsevier
We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19
patients and evaluate its potential as a source of biomarkers for the management of the …

[HTML][HTML] A community approach to mortality prediction in sepsis via gene expression analysis

…, AM Choi, JF Bermejo-Martin, R Almansa… - Nature …, 2018 - nature.com
Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical
severity scores and available assays such as blood lactate reflect global illness severity …

[HTML][HTML] Host adaptive immunity deficiency in severe pandemic influenza

…, I Martin-Loeches, J Rello, A Antón, R Almansa… - Critical Care, 2010 - Springer
… Viral load in pharynx showed a direct correlation with SOFA score (r = 0.4) and an inverse
one with O 2 saturation (r = -0.3) during the course of the disease. Five MV patients suffered …