The role of the monoamines dopamine (DA) and serotonin (5HT) and the monoamine-metabolizing
enzyme monoamine oxidase A (MAOA) have been repeatedly implicated in studies …

Alterations in DNA methylation have been associated with alcohol exposure and proposed
to contribute to continued alcohol use; however, the molecular mechanisms involved remain …

Alcohol-use disorders encompass a range of drinking levels and behaviors, including low,
binge, and heavy drinking. In this regard, investigating the neural state of individuals who …

Rhesus macaques are an important pre-clinical model of human disease. To advance our
understanding of genomic variation that may influence disease, we surveyed genome-wide …

Background Amyloid beta (Aβ) plaque density was examined in the amygdala of rhesus
macaques, to elucidate the influence of age, diet and hormonal environment. Methods Luminex …

The underlying genetic and epigenetic mechanisms driving functional adaptations in neuronal
excitability and excessive alcohol intake are poorly understood. Small-conductance Ca 2…

The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission
in mammals are poorly understood. Genetic bottleneck in female germ cells has been …

Alcohol use disorder (AUD) is a chronic condition with devastating health and socioeconomic
effects. Still, pharmacotherapies to treat AUD are scarce. In a prior study aimed at …

Obesity, the cessation of ovarian steroids with menopause, and age are risk factors for mood
disorders, dementia, and Alzheimer’s disease (AD). However, immediate hormone therapy (…

Background In 1990, David Barker proposed that prenatal nutrition is directly linked to adult
cardiovascular disease. Since then, the relationship between adult cardiovascular risk, …