User profiles for R. Kouyos
 | Roger D. KouyosUniversity of Zurich; University Hospital Zurich Verified email at uzh.ch Cited by 7999 |
Population biological principles of drug-resistance evolution in infectious diseases
The emergence of resistant pathogens in response to selection pressure by drugs and their
possible disappearance when drug use is discontinued are evolutionary processes common …
possible disappearance when drug use is discontinued are evolutionary processes common …
The state of affairs in the kingdom of the Red Queen
One of the most prominent hypotheses to explain the ubiquity of sex and recombination is
based on host–parasite interactions. Under the name of the Red Queen hypothesis (RQH), it …
based on host–parasite interactions. Under the name of the Red Queen hypothesis (RQH), it …
Epistasis between deleterious mutations and the evolution of recombination
Epistasis and the evolution of recombination are closely intertwined: epistasis generates
linkage disequilibria (ie statistical associations between alleles), whereas recombination …
linkage disequilibria (ie statistical associations between alleles), whereas recombination …
A highly virulent variant of HIV-1 circulating in the Netherlands
…, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos… - Science, 2022 - science.org
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log 10 increase (ie, a ~3.5-fold to 5.5-…
nine individuals with this variant had a 0.54 to 0.74 log 10 increase (ie, a ~3.5-fold to 5.5-…
Estimating the basic reproductive number from viral sequence data
… However, as there is no correlation between the size of the subepidemic and R 0 in our
study, there is no evidence that our estimate R 0 overestimates the true R 0 in the entire Swiss …
study, there is no evidence that our estimate R 0 overestimates the true R 0 in the entire Swiss …
Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland
Background . Sequence data from resistance testing offer unique opportunities to characterize
the structure of human immunodeficiency virus (HIV) infection epidemics. Methods . We …
the structure of human immunodeficiency virus (HIV) infection epidemics. Methods . We …
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
…, ES Svarovskaia, H Mo, RD Kouyos… - Proceedings of the …, 2011 - National Acad Sciences
The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C
virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and …
virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and …
[HTML][HTML] Determinants of HIV-1 broadly neutralizing antibody induction
Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet
basic aspects of their induction remain poorly understood. Here we report on viral, host and …
basic aspects of their induction remain poorly understood. Here we report on viral, host and …
Cohort profile update: the Swiss HIV cohort study (SHCS)
…, C Kahlert, A Trkola, RD Kouyos… - International journal …, 2022 - academic.oup.com
The Swiss HIV Cohort Study (SHCS) provides a unique research platform for clinical,
translational, epidemiological, social and basic research. The SHCS was established in 1988. It is …
translational, epidemiological, social and basic research. The SHCS was established in 1988. It is …
Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection
Background. The time passed since the infection of a human immunodeficiency virus (HIV)–infected
individual (the age of infection) is an important but often only poorly known quantity. …
individual (the age of infection) is an important but often only poorly known quantity. …