All blood cell lineages derive from a common hematopoietic stem cell (HSC). The current
model implicates that the first lineage commitment step of adult pluripotent HSCs results in a …

The major myeloid blood cell lineages are generated from hematopoietic stem cells by
differentiation through a series of increasingly committed progenitor cells. Precise …

The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly
understood. Herein we demonstrate that thrombopoietin (THPO) and its receptor, MPL, are …

… The R environment of the R Project for Statistical Computing was used for statistical analysis…
Sprague and R. Sasik for microarray analysis; and members of the Murre laboratory for …

During an organism's ontogeny and in the adult, each B and T lymphocyte generates a
unique antigen receptor, thereby creating the organism's ability to respond to a vast number of …

Recent studies implicated the existence of adult lymphoid-primed multipotent progenitors (LMPPs)
with little or no megakaryocyte-erythroid potential, questioning common myeloid and …

Mutations in the CEBPA gene are present in 7%–10% of human patients with acute myeloid
leukemia (AML). However, no genetic models exist that demonstrate their etiological …

The genome is folded into domains located in compartments that are either transcriptionally
inert or transcriptionally permissive. Here we used genome-wide strategies to characterize …

The first lymphoid-restricted progeny of hematopoietic stem cells (HSCs) are lymphoid-primed
multipotent progenitors (LMPPs), which have little erythromyeloid potential but retain …

The present review focuses on the interaction of microgels and microcapsules with biological
macromolecules, particularly peptides and proteins, as well as drug delivery applications …