The process of cancer metastasis involves a series of sequential and complex steps. Here
we give a perspective on recent results regarding noncoding transcription in cancer …

RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …

RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high-…

Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …

… For each transcript functional site and its flanking regions, we demand a stringent R score
for thousands of transcripts being compared. We generated roughly the same number of …

… The false discovery rate (FDR) of the significance of the structural change at the SNV site
is estimated by a multi-hypothesis testing performed using the p.adjust function in R. A SNV is …

RNA structure has important roles in practically every facet of gene regulation, but the paucity
of in vivo structural probes limits current understanding. Here we design, synthesize and …

DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle
1 , but the molecular underpinnings of their involvement, particularly in mammalian cells, …

Efforts to use RNA-cleaving DNA enzymes (DNAzymes) as gene-silencing agents in therapeutic
applications have stalled due to their low efficacy in clinical trials. Here we report a xeno…

iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated
inflammatory responses. Yet, microglia are highly sensitive to their environment, …