Although the origin of mitochondria from the endosymbiosis of an α‐proteobacterium is well
established, the nature of the host cell, the metabolic complexity of the endosymbiont and …

… MtDNA-less mouse cells (r L929) were grown in DMEM supplemented with 5% FBS, 50
mg/ml uridine, and 1 mM pyruvate (r medium) and in the presence of 250 mg/ml of geneticin (…

Oxygen radical formation in mitochondria is an incompletely understood attribute of
eukaryotic cells. Recently, a kinetic model was proposed, in which the ratio between electrons …

… This creates two forms of methionine sulfoxide, S and R. The two diastereomers can be
reduced by the peptide methionine sulfoxide reductases A (MsrA) and B (Msr B). Both sulfoxide …

We studied a group of individuals with elevated urinary excretion of 3-methylglutaconic acid,
neutropenia that can develop into leukemia, a neurological phenotype ranging from …

Mitochondrial oxidative phosphorylation (OXPHOS) is responsible for generating the majority
of cellular ATP. Complex III (ubiquinol-cytochrome c oxidoreductase) is the third of five …

… Szklarczyk and J.Heringa … Having scorew and jmax calculated, we can obtain the
relative contribution of a residue r in the k-th column of the profile prel(r, k) = …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

Mitochondrial disorders, characterized by clinical symptoms and/or OXPHOS deficiencies,
are caused by pathogenic variants in mitochondrial genes. However, pathogenic variants in …

Background Orthology is a central tenet of comparative genomics and ortholog identification
is instrumental to protein function prediction. Major advances have been made to determine …