Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets

ML Herlocher, R Truscon, S Elias… - Journal of Infectious …, 2004 - academic.oup.com
Three type A influenza viruses, each of which has a distinct neuraminidase-gene mutation
and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in …

[HTML][HTML] Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines

…, JR Rotthoff, ER Teich, RK Truscon… - … England Journal of …, 2006 - Mass Medical Soc
Background The efficacy of influenza vaccines may decline during years when the circulating
viruses have antigenically drifted from those included in the vaccine. Methods We carried …

[HTML][HTML] Comparative efficacy of inactivated and live attenuated influenza vaccines

…, JG Petrie, E Johnson, R Truscon… - … England Journal of …, 2009 - Mass Medical Soc
Background The efficacy of influenza vaccines may vary from year to year, depending on a
variety of factors, and may differ for inactivated and live attenuated vaccines. Methods We …

Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets

ML Herlocher, J Carr, J Ives, S Elias, R Truscon… - Antiviral research, 2002 - Elsevier
A model of influenza transmission has been established in ferrets in which wild-type influenza
infection in a donor ferret can be transmitted sequentially to other ferrets. We have studied …

Persistence of antibodies to influenza hemagglutinin and neuraminidase following one or two years of influenza vaccination

…, SE Ohmit, E Johnson, R Truscon… - The Journal of …, 2015 - academic.oup.com
Background. Antibody titers to influenza hemagglutinin (HA) and neuraminidase (NA)
surface antigens increase in the weeks after infection or vaccination, and decrease over time …

Detection and control of influenza outbreaks in well-vaccinated nursing home populations

…, E Teich, ML Herlocher, R Truscon… - Clinical Infectious …, 2004 - academic.oup.com
Background. Influenza outbreaks continue to occur in nursing homes despite high vaccination
coverage among residents. Recommendations for outbreak control in institutions such as …

Prevention of symptomatic seasonal influenza in 2005–2006 by inactivated and live attenuated vaccines

…, JC Victor, ER Teich, RK Truscon… - The Journal of …, 2008 - academic.oup.com
Background. The efficacy of influenza vaccines may vary annually. In 2004–2005, when
antigenically drifted viruses were circulating, a randomized, placebo-controlled trial involving …

[HTML][HTML] Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

K Debbink, JT McCrone, JG Petrie, R Truscon… - PLoS …, 2017 - journals.plos.org
… True positive SNV were identified from the raw output tables by applying the following
filtering criteria in R: (i) Bonferonni corrected p value <0.01, (ii) average MapQ score on variant …

Ferrets as a Transmission Model for Influenza: Sequence Changes in HA1 of Type A (H3N2) Virus

ML Herlocher, S Elias, R Truscon… - The Journal of …, 2001 - academic.oup.com
Ferrets were used as an animal model to study whether controlled transmission of type A
influenza is similar to human transmission when sequence changes in HA1 are used as the …

Modest waning of influenza vaccine efficacy and antibody titers during the 2007–2008 influenza season

JG Petrie, SE Ohmit, R Truscon… - The Journal of …, 2016 - academic.oup.com
Background. Antibody titers decrease with time following influenza vaccination, raising
concerns that vaccine efficacy might wane. However, the relationship between time since …