Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation
has profoundly evolved over the past years. The way drugs targeting this family of receptors …

G protein-coupled receptors (GPCRs) play crucial roles in the ability of target organs to respond
to hormonal cues. GPCRs’ activation mechanisms have long been considered as a two-…

Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) have been considered
biologically equivalent because of their structural similarities and their binding to the same …

Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction.
It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the …

This paper considers the behavior of discrete and continuous mathematical models for gene
expression in the presence of transcriptional/translational bursting. We treat this problem in …

We present recent results on Piecewise Deterministic Markov Processes (PDMPs), involved
in biological modeling. PDMPs, first introduced in the probabilistic literature by [30], are a …

Biased signaling has recently emerged as an interesting means to modulate the function of
many G protein-coupled receptors (GPCRs). Previous studies reported two negative …

… Again assuming that the amount of repressor R bound to the operator O is small we have
f ( E ) = 1 + K 1 E n 1 + ( K 1 + K 2 R tot ) E n = 1 + K 1 E n 1 + KE n , where K=K 1 +K 2 R tot . …

Motivated by nucleation and molecular aggregation in physical, chemical, and biological
settings, we present a thorough analysis of the general problem of stochastic self-assembly of a …

This paper considers adiabatic reduction in a model of stochastic gene expression with
bursting transcription considered as a jump Markov process. In this model, the process of gene …