User profiles for S. A. Ament

Seth A. Ament, Ph.D.

University of Maryland School of Medicine
Verified email at som.umaryland.edu
Cited by 6164

Nutritional regulation of division of labor in honey bees: toward a systems biology perspective

SA Ament, Y Wang, GE Robinson - … Reviews: Systems Biology …, 2010 - Wiley Online Library
… above, as many as 40% of genes are differentially expressed in the brains of nurses and
foragers,22 and a similarly large number of genes change expression in the fat cells (Ament

[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse

…, X Wang, F Xie, AM Yanny, R Zhang, SA Ament… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development

…, D Bogdanoff, A Kreimer, KS Pollard, SA Ament… - Nature, 2021 - nature.com
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape 1 . In the developing brain, …

Rediscovering the value of families for psychiatric genetics research

…, EEM Knowles, SR Mathias, SA Ament… - Molecular …, 2019 - nature.com
As it is likely that both common and rare genetic variation are important for complex disease
risk, studies that examine the full range of the allelic frequency distribution should be utilized …

Insulin signaling is involved in the regulation of worker division of labor in honey bee colonies

SA Ament, M Corona, HS Pollock… - Proceedings of the …, 2008 - National Acad Sciences
It has been proposed that one route of behavioral evolution involves novel regulation of
conserved genes. Age-related division of labor in honey bee colonies, a highly derived …

[HTML][HTML] The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia

SA Ament, A Poulopoulos - Current opinion in neurobiology, 2023 - Elsevier
Transcriptomic approaches are powerful strategies to map the molecular diversity of cells in
the brain. Single-cell genomic atlases have now been compiled for entire mammalian brains…

[HTML][HTML] A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

…, F Xie, S Fischer, RS Adkins, AI Aldridge, SA Ament… - Nature, 2021 - nature.com
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain 1 , 2 – 3 . With the proliferation of multi-omics …

Rare variants in neuronal excitability genes influence risk for bipolar disorder

SA Ament, S Szelinger, G Glusman… - Proceedings of the …, 2015 - National Acad Sciences
We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar
disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on …

Behavior-specific changes in transcriptional modules lead to distinct and predictable neurogenomic states

S Chandrasekaran, SA Ament… - Proceedings of the …, 2011 - National Acad Sciences
Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct
behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic …

gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

…, B Herb, C Colantuoni, RL Carter, SA Ament… - Nature …, 2021 - nature.com
To the Editor—Biologists are important stakeholders in genomic data, both as data generators
and as users of genomic data resources. Tools to efficiently visualize and analyze multi-…