Hyaluronan (HA) is a large but simple glycosaminoglycan composed of repeating D-glucuronic
acid, β1–3 linked to N-acetyl-D-glucosamine β1–4, found in body fluids and tissues, in …

Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique capacity
to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by one or …

Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave
aggrecan preferentially in the chondroitin sulfate–2 (CS-2) domain and secondarily at the E …

A heterozygous single base change in exon 49 of COL1A1, which converted the codon for
proα1(I) carboxyl-terminal propeptide residue 94 from tryptophan (TGG) to cysteine (TGT) was …

Objective To determine whether an aggrecan 32‐mer fragment derived from dual ADAMTS
and matrix metalloproteinase (MMP) cleavage in the aggrecan interglobular domain was …

Pain is the predominant symptom of osteoarthritis, but the connection between joint damage
and the genesis of pain is not well understood. Loss of articular cartilage is a hallmark of …

Proteolysis of the cartilage proteoglycan aggrecan is a feature of arthritis. We present a
method for analyzing aggrecanolysis in in vitro cultures of 3-week-old mouse femoral head …

Objective To characterize aggrecan catabolism and the overall phenotype in mice deficient
in both ADAMTS‐4 and ADAMTS‐5 (TS‐4/TS‐5 Δ‐cat) activity. Methods Femoral head …

… GOLUB University of Melbourne, Department of Paediatrics, Royal Children's Hospital,
Parkville, Vic. 3052, Australia … JF Bateman and SB Golub … JF Bateman and SB Golub …

In the mouse, proteolysis in the aggrecan interglobular domain is driven by ADAMTS-5, and
mice deficient in ADAMTS-5 catalytic activity are protected against aggrecan loss and …