Myc family proteins promote cancer by inducing widespread changes in gene expression.
Their rapid turnover by the ubiquitin–proteasome pathway is regulated through …

The Myc proteins comprise a family of ubiquitous regulators of gene expression implicated in
over half of all human cancers. They interact with a large number of other proteins, such as …

Protein kinases are central players in the regulation of cell cycle and signalling pathways.
Their catalytic activities are strictly regulated through post‐translational modifications and …

Acomplex of transforming acidic coiled-coil protein 3 (TACC3), colonic and hepatic tumor
overexpressed gene (ch-TOG), and clathrin has been implicated in mitotic spindle assembly …

Aurora A kinase is a master mitotic regulator whose functions are controlled by several
regulatory interactions and post-translational modifications. It is frequently dysregulated in cancer…

Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and
Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by …

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and
its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic …

The mitotic kinase Aurora-A and its partner protein TPX2 (Targeting Protein for Xenopus
kinesin-like protein 2) are overexpressed in cancers, and it has been proposed that they work …

Aurora‐A regulates the recruitment of TACC 3 to the mitotic spindle through a phospho‐dependent
interaction with clathrin heavy chain ( CHC ). Here, we describe the structural basis of …

The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule
polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily …