Variance component model to account for sample structure in genome-wide association studies

HM Kang, JH Sul, SK Service, NA Zaitlen, S Kong… - Nature …, 2010 - nature.com
Although genome-wide association studies (GWASs) have identified numerous loci associated
with complex traits, imprecise modeling of the genetic relatedness within study samples …

Common variants associated with plasma triglycerides and risk for coronary artery disease

…, AK Petersen, S Sanna, R Saxena, SK Service… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

C Sabatti, SK Service, AL Hartikainen, A Pouta… - Nature …, 2009 - nature.com
Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation
of environmental and genetic influences on complex traits. We report GWAS results for …

Systems biology of the vervet monkey

AJ Jasinska, CA Schmitt, SK Service, RM Cantor… - Ilar …, 2013 - academic.oup.com
Service, MS, is senior statistician in the Center for Neurobehavioral Genetics at UCLA in Los
Angeles, California. Rita M. Cantor, PhD, is Professor in the Department of Human Genetics …

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

…, AK Petersen, S Sanna, R Saxena, SK Service… - Science, 2016 - science.org
SK has financial relationships with Novartis, Aegerion, Bristol-Myers Squibb, Sanofi,
AstraZeneca, Alnylam, Eli Lilly, … Please read our Terms of Service before submitting an eLetter. …

Genome-wide association study of Tourette's syndrome

…, P Evans, E Gamazon, CK Edlund, SK Service… - Molecular …, 2013 - nature.com
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial
recurrence rates among neuropsychiatric diseases with complex inheritance. However, the …

Exome sequencing of Finnish isolates enhances rare-variant association power

AE Locke, KM Steinberg, CWK Chiang, SK Service… - Nature, 2019 - nature.com
Exome-sequencing studies have generally been underpowered to identify deleterious
alleles with a large effect on complex traits as such alleles are mostly rare. Because the …

Clinical and panoramic predictors of femur bone mineral density

SC White, A Taguchi, D Kao, S Wu, SK Service… - Osteoporosis …, 2005 - Springer
Dentists are a potentially valuable resource for initial patient screening for signs of osteoporosis,
as individuals with osteoporosis have altered architecture of the inferior border of the …

Decomposition of dissolved DMSP and DMS in estuarine waters: dependence on temperature and substrate concentration

RP Kiene, SK Service - Marine Ecology Progress Series, 1991 - JSTOR
Dimethylsulfide (DMS) is an important trace gas which is emitted from seawater to the
atmosphere. DMS is believed to be derived primarily from the plant osmolyte 3-(dimethylsulfonium)…

Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the …

…, J Miettunen, A Palotie, L Penke, SK Service… - …, 2012 - academic.oup.com
Personality traits are basic dimensions of behavioral variation, and twin, family, and adoption
studies show that around 30% of the between-individual variation is due to genetic variation…