Microtubules form important cytoskeletal structures that play a role in establishing and
maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and …

RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1].
Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss of function of a putative …

Rim1 was previously identified as a Rab3 effector localized to the presynaptic active zone in
vertebrates. Here we demonstrate that C. elegans unc-10 mutants lacking Rim are viable, …

Structural DNA nanotechnology seeks to build synthetic molecular machinery from DNA.
DNA nanomachines are artificially designed assemblies that switch between defined …

The encapsulation of molecular cargo within well-defined supramolecular architectures is
highly challenging. Synthetic hosts are desirable because of their well-defined nature and …

Background Tissue-specific alternative pre-mRNA splicing is a widely used mechanism for
gene regulation and the generation of different protein isoforms, but relatively little is known …

Increased Tau protein amyloidogenicity has been causatively implicated in several
neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau …

The polarized distribution of neuronal proteins to axons and dendrites relies on microtubule-binding
proteins such as CRMP, directed motors such as the kinesin UNC-104 (Kif1A) and …

JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were
known to be adaptors linking cargo to Kinesin‐I, a major molecular motor for axonal transport. …

High concentration of cytoskeletal filaments, organelles, and proteins along with the space
constraints due to the axon’s narrow geometry lead inevitably to intracellular physical …