Background Autoimmune disease-associated variants are preferentially found in regulatory
regions in immune cells, particularly CD4 + T cells. Linking such regulatory regions to gene …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade,
suggesting a role for non-genetic factors such as epigenetic mechanisms in disease …

… The shales contain abundant irridescent Kosmoceras sp. and the common belemn- … At
Stanton Harcourt the fauna of the Mariae Clay includes abundant pyritised moulds of Dicroloma sp…

Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B,
indicated to prevent recurrence of C. difficile infection (rCDI) in high-risk adults receiving …

… sp. found in the river. Experiments were conducted in flowing water systems known as raceways.
… Sodium sulphate was considerably more toxic to Tricorythus sp. than sodium chloride. …

GWAS variants commonly map to DNA regulatory regions, many of which are located away
from their target genes, coming into their proximity through 3D chromosomal interactions. We …

… BAYNARD OF LACKHAM GROVE OF DONHEAD 22 BAYNTON OF ROWLSTON BECKETT
OF LITTLETON BELLINGHAM OF ORSTON ST. GEORGE BENNETT OF NORTON BAVENT …

… Within 20 yr from diagnosis, the majority of RR-MS patients will convert to a secondary-progressive
form (SP-MS) characterized by a persistent increase in disability. In ~10% of patients, …

Memory T cells provide long-lasting defense responses through their ability to rapidly reactivate,
but how they efficiently “recall” an inflammatory transcriptional program remains unclear…