High-throughput sequencing, also known as next-generation sequencing (NGS), has
revolutionized genomic research. In recent years, NGS technology has steadily improved, with …

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the
mammalian genome, many of which have important roles in regulating a variety of biological …

Here, we generated a genome-scale shRNA library targeting long intergenic noncoding
RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse …

Vaccinia virus (VACV) was used as the vaccine strain to eradicate smallpox. VACV is still
administered to healthcare workers or researchers who are at risk of contracting the virus, and …

A major challenge for kidney transplantation is balancing the need for immunosuppression
to prevent rejection, while minimizing drug‐induced toxicities. We used DNA microarrays (HG…

Pseudomonas aeruginosa infections can be virtually impossible to eradicate, and the evolution
of resistance during antibiotic therapy is a significant concern. In this study, we use DNA …

Background Lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent
of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A …

Microbiomes are vast communities of microorganisms and viruses that populate all natural
ecosystems. Viruses have been considered to be the most variable component of …

We performed a randomized prospective trial comparing calcineurin inhibitor (CNI)-free to
CNI-based immunosuppression to determine the impact on renal function, structure and gene …

Results from clinical and imaging studies provide evidence for changes in schizophrenia
with disease progression, however, the underlying molecular differences that may occur at …