When reporting research findings, scientists document the steps they followed so that others
can verify and build upon the research. When those steps have been described in sufficient …

We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…

Gene-expression microarrays allow researchers to characterize biological phenomena in a
high-throughput fashion but are subject to technological biases and inevitable variabilities …

Motivation: The Cancer Genome Atlas (TCGA) RNA-Sequencing data are used widely for
research. TCGA provides ‘Level 3’ data, which have been processed using a pipeline specific …

Background Improvements to prognostic models in metastatic castration-resistant prostate
cancer have the potential to augment clinical trial design and guide treatment strategies. In …

Metastatic breast cancer remains challenging to treat, and most patients ultimately progress
on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (…

Over the past two decades, many biotechnology platforms have been developed for high-throughput
gene expression profiling. However, because each platform is subject to technology…

Computer programming is a fundamental tool for life scientists, allowing them to carry out
many essential research tasks. However, despite a variety of educational efforts, learning to …

Public compendia of sequencing data are now measured in petabytes. Accordingly, it is
infeasible for researchers to transfer these data to local computers. Recently, the National …

Identifying accurate biomarkers of cognitive decline is essential for advancing early
diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM …