Polymeric multilayer capsules in drug delivery

LJ De Cock, S De Koker, BG De Geest… - Angewandte Chemie …, 2010 - Wiley Online Library
De Koker et al. inhibited different endocytotic pathways and actin polymerization and carried
out a detailed confocal and transmission electron microscopy investigation of protrusions of …

Polymeric multilayer capsules for drug delivery

S De Koker, R Hoogenboom… - Chemical Society Reviews, 2012 - pubs.rsc.org
… A first detailed study on the in vivo behaviour of PMLC was reported by De Koker and co-…
capsules (ie) has also been addressed by De Koker and co-workers. Upon instillation in the …

Polyelectrolyte microcapsules for biomedical applications

BG De Geest, S De Koker, GB Sukhorukov, O Kreft… - Soft Matter, 2009 - pubs.rsc.org
… Stefaan De Koker Stefaan De Koker graduated as a bio-engineer from Ghent University
in 2001. He started his PhD at the VIB, at the Department for Molecular Biomedical …

[PDF][PDF] Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

…, A Kaczmarek, T Delvaeye, B De Craene, S De Koker… - Cell reports, 2016 - cell.com
Successful immunogenic apoptosis in experimental cancer therapy depends on the induction
of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is …

[HTML][HTML] Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines

…, P Bogaert, J Grooten, G Vanham, S De Koker - Molecular Therapy, 2013 - cell.com
The use of DNA and viral vector-based vaccines for the induction of cellular immune
responses is increasingly gaining interest. However, concerns have been raised regarding the …

In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules

S De Koker, BG De Geest, C Cuvelier… - Advanced Functional …, 2007 - Wiley Online Library
Polyelectrolyte microcapsules are made by layer‐by‐layer (LbL) coating of a sacrificial
template, followed by decomposition of the template, to produce hollow microcapsules. In this …

[PDF][PDF] Polyelectrolyte microcapsules as antigen delivery vehicles to dendritic cells: uptake, processing, and cross‐presentation of encapsulated antigens

S De Koker, BG De Geest, SK Singh… - Angewandte …, 2009 - academia.edu
One of the major challenges for medicine today is undoubtedly the development of vaccines
that can generate strong T-cell responses along with robust antibody-mediated immune …

[HTML][HTML] mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

…, T Bastogne, RM Schiffelers, S De Koker - Molecular Therapy, 2022 - cell.com
… Stefaan De Koker Stefaan De Koker … In (E) and (F), statistics were assessed by one-way
ANOVA with Sidak’s multiple comparison test. ∗∗∗p < 0.001; ns, not significant. …

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

…, SA David, S De Koker, BG De Geest - Proceedings of the …, 2016 - National Acad Sciences
Agonists of Toll-like receptors (TLRs) are potent activators of the innate immune system and
hold promise as vaccine adjuvant and for anticancer immunotherapy. Unfortunately, in …

Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules

P Rivera-Gil, S De Koker, BG De Geest, WJ Parak - Nano letters, 2009 - ACS Publications
Multilayer polyelectrolyte capsules made by layer-by-layer assembly of oppositely charged
biodegradable polyelectrolytes were filled with a model of a nonactive prodrug, a self-…