Precursor mRNA splicing is one of the most highly regulated processes in metazoan species.
In addition to generating vast repertoires of RNAs and proteins, splicing has a profound …

RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …

… Error bars: 95% confidence intervals, Pearson’s χ 2 proportion tests. Analyses of predictive …
classifying AS events and the other species-specific AS events are indicated (Student’s t test). …

… Exons with inclusion levels that significantly correlate with the PSI of exon 9 (P < 0.05,
Pearson’s product-moment correlation) are enriched in genes functionally associated with …

… on dry ice (5 min on ice followed by $30 s in a 37 C water bath). For harsh lysis, lysates
were additionally subject to sonication (20 1 s pulses with 1 s in between at 30% power). For …

In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain
elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we …

Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including
the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new …

In eukaryotes, messenger RNA (mRNA) is transcribed in the nucleus and must be exported
into the cytoplasm to access the translation machinery. Although the nuclear export of mRNA …

Background: Cytotoxic T lymphocytes (CTLs) are a key driver of the anti-tumor immune
response. Understanding the molecular mechanisms mediating this process can reveal …