User profiles for S. Holden

Stein T Holden

- Verified email at nmbu.no - Cited by 13998

Séamus Holden

- Verified email at warwick.ac.uk - Cited by 3469

Sinead Holden

- Verified email at ucdconnect.ie - Cited by 2731

Drug design by machine learning: support vector machines for pharmaceutical data analysis

R Burbidge, M Trotter, B Buxton, S Holden - Computers & chemistry, 2001 - Elsevier
We show that the support vector machine (SVM) classification algorithm, a recent
development from the machine learning community, proves its potential for structure–activity …

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH‐dependent solubility the Achilles heel of targeted therapy?

…, MR Yago, MJ Dresser, SN Holden… - Clinical …, 2012 - Wiley Online Library
A majority of the novel orally administered, molecularly targeted anticancer therapies are
weak bases that exhibit pH‐dependent solubility, and suppression of gastric acidity with acid‐…

Treatment and prevention of acute and recurrent ankle sprain: an overview of systematic reviews with meta-analysis

…, C Bleakley, E Delahunt, S Holden - British journal of sports …, 2017 - bjsm.bmj.com
… If you wish to reuse any or all of this article please use the link below which will take you to
the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and …

Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload

LJ Anderson, S Holden, B Davis, E Prescott… - European heart …, 2001 - academic.oup.com
Aims To develop and validate a non-invasive method for measuring myocardial iron in
order to allow diagnosis and treatment before overt cardiomyopathy and failure develops. …

Differentiation and reversal of malignant changes in colon cancer through PPARγ

…, JB Partridge, SA Holden, LB Chen, S Singer… - Nature medicine, 1998 - nature.com
PPARγ is a nuclear receptor that has a dominant regulatory role in differentiation of cells of
the adipose lineage, and has recently been shown to be expressed in the colon. We show …

Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab

FA Scappaticci, JR Skillings, SN Holden… - Journal of the …, 2007 - academic.oup.com
… P value for the rate per 100 py is from Poisson regression, that for the hazard ratios is from
log-rank test, and that for the percentage incidence is from Fisher’s exact test. All statistical …

[HTML][HTML] Democratising deep learning for microscopy with ZeroCostDL4Mic

…, PK Mattila, E Karinou, S Holden… - Nature …, 2021 - nature.com
… To make ZeroCostDL4Mic as easy to use as possible, we exploited the Jupyter Notebooks’
code readability and Colab’s integration of code input via a graphical user interface (GUI). …

[PDF][PDF] Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer

…, S Modi, SF Jones, SN Holden, W Yu, S Girish… - J Clin Oncol, 2010 - academia.edu
… While trastuzumab’s mechanism of action is not fully … Elucidating the mechanism of T-DM1’s
effects on platelet levels is an active area of investigation. Reversible elevations in hepatic …

A circuit mechanism for differentiating positive and negative associations

…, GG Calhoon, SA Halbert, R Wichmann, SS Holden… - Nature, 2015 - nature.com
The ability to differentiate stimuli predicting positive or negative outcomes is critical for
survival, and perturbations of emotional processing underlie many psychiatric disease states. …

Resource degradation and adoption of land conservation technologies in the Ethiopian highlands: a case study in Andit Tid, North Shewa

B Shiferaw, ST Holden - Agricultural economics, 1998 - Wiley Online Library
This paper reports results from a study of resource degradation and conservation behavior
of peasant households in a degraded part of the Ethiopian highlands. Peasant households' …