The insulin (INS) region is the second most important locus associated with Type 1 Diabetes
(T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the …

None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D)
was shown to have a functional effect. To test if the epigenetic variation could play a …

In two cohorts of 174 and 165 obese Caucasian children, we measured insulin sensitivity
and genotyped insulin receptor substrate IRS-1 and IRS-2 genes for the Arg972Gly and the …

… Sophie Le Fur; Sophie Le Fur … The conditions on which Randle et al.’s hypothesis can hold
in clinical situations are 1) lipid oxidation is increased, 2) glucose oxidation is decreased, and …

IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in
immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to …

Characterizing the paleoenvironmental context of the first hominids is a key issue for
understanding their behavioral and morphological evolution. The present study aims at …

… years that corresponds to a rounding of the patient’s age at diagnostic. In both analyses, we
used non-rounded patient’s age at diagnostic for both the patient and his matched controls. …

Our objective was to test the ventricular repolarization response to a controlled hypoglycaemia
test in Type 1 diabetic adolescents, an age group at risk for ‘dead in bed syndrome’. We …

… ID alleles had a comparable proportion of A, C, J, and S repeats but fewer B and more F …
S. Le Fur was supported by a research grant from the Centre National de Génotypage (Evry, …

… Our approach of children’s exposures could be complementary to this strategy, either by
providing suspect factors to future exposome analyses, or by testing exposome-driven …