Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in
pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular thiols, …

… It is thus conceivable that a high FFA load, that exceeds the β-cell’s esterification capacity,
impairs ER functions and triggers an ER stress response, thus contributing to β-cell toxicity. …

Antioxidative defence mechanisms of pancreatic β-cells are particularly weak and can be
overwhelmed by redox imbalance arising from overproduction of reactive oxygen and reactive …

… The homogenates were sonicated on ice for 1 min in 15-s bursts at 90 W with a Braun-Sonic
125 sonifier. Thereafter the homogenates were centrifuged at 35,000$ and 4C for 40 min, …

Using a sensitive Northern blot hybridization technique, gene expression of superoxide
dismutase (SOD), catalase, and glutathione peroxidase was studied in pancreatic islets and for …

… Tiedge M, Lortz S, Drinkgern J, Lenzen S 1997) Relation between antioxidant enzyme
gene … Lenzen S 1979) Insulin secretion by isolated perfused rat and mouse pancreas. Am J …

In 1838 there appeared the publication by Friedrich Wrhler and Justus Liebig on the nature
of uric acid [1]. Wrhler, professor of chemistry and pharmacology at the University of Grttingen…

… Tiedge M, Lortz S, Drinkgern J, Lenzen S: Relation between antioxidant enzyme gene
expression and antioxidative defense status of insulin-producing cells. D iabetes 46:1733–1742, …

Chronically elevated concentrations of non‐esterified fatty acids (NEFAs) in type 2 diabetes
may be involved in β‐cell dysfunction and apoptosis. It has been shown that long‐chain …

… In brief, cells were homogenized in PBS (pH 7.4) through sonication on ice for 1 min in 15-s
bursts at 90 watts. Catalase activity was measured by ultraviolet spectroscopy, monitoring …