Cytokine dysregulation is believed to play a key role in the remodeling of the immune system
at older age, with evidence pointing to an inability to fine-control systemic inflammation, …

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The genetic contribution to the variation in human lifespan is ∼25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence population …

We have previously reported the presence of Hsp60 and Hsp70 in the peripheral circulation
of normal individuals. Given that the capacity to generate stress proteins declines with age, …

Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR
upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), …

Background: an increase in mean platelet volume and a decrease in platelet total have
been reported following stroke and increased mean platelet volume in acute myocardial …

Understanding how to ‘Age Longer and Age Well’ is a priority for people personally, for
populations globally and for government policy. Nonagenarians are the oldest members of our …

Cytokines, the central regulators of leucocyte growth and differentiation, are produced by a
wide variety of cell types, target various cell subsets and exhibit numerous biological activities…

Aging has been shown to be accompanied by various changes in the lymphocyte subset
distribution in the elderly. We have investigated more fully, and in a large number of subjects, …

In this study, we have assessed any change in the frequency of the GG homozygotes of the
174 IL-6 polymorphism with increasing age, arguing that if IL-6 tracks with functional …