… The recurrence risk for affected siblings (λ s ) was estimated to be between 4 and 10 [73].
Twin studies reveal a … However, association signals identified in this study accounted for λ s …

Psoriasis is a chronic inflammatory multi organ disease with well characterized pathology
occurring in the skin and often the joints. Although the disease has many characteristic and …

… Soumya Raychaudhuri … Direct views of the peptide-binding groove are presented, showing
key amino acid positions identified in an association analysis by Raychaudhuri, S. et al. Nat. …

Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…