User profiles for S. Sengstake

Sarah Sengstake

Scientific Expert, Institute of Tropical Medicine, Antwerp
Verified email at itg.be
Cited by 302

Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite?

AL den Hertog, S Sengstake… - Pathogens and …, 2015 - academic.oup.com
… It could be claimed that this is simply due to the fact that PZA resistance is rapidly generated
… ’ reveals a significant cost to PZA resistance which is difficult for the bacterium to circumvent. …

[HTML][HTML] Combined Species Identification, Genotyping, and Drug Resistance Detection of Mycobacterium tuberculosis Cultures by MLPA on a Bead-Based Array

I Bergval, S Sengstake, N Brankova, V Levterova… - 2012 - journals.plos.org
… In areas where TB is less prevalent or where TB is prevalent … One consequence is that
molecular typing and, to some extent… a strain is identified as Beijing if the RD105 region is deleted …

[HTML][HTML] Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment

…, MC Schechter, M Seifert, S Sengstake… - European …, 2022 - Eur Respiratory Soc
… (CC) is effectively that of an ECOFF (ie it is set based on MIC … ) even though the CC is
actually used as a CB S/R (ie pWT … is moxifloxacin (table 1), for which the CC is used as a CB S

CD21 and CD62L shedding are both inducible via P2X7Rs

S Sengstake, EM Boneberg, H Illges - International immunology, 2006 - academic.oup.com
… BzATP is able to induce … CD21 is also susceptible to BzATP-induced shedding on peripheral
B cells. In addition, using receptor inhibitiors, we show that shedding of CD21 and CD62L is

[HTML][HTML] Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia

S Sengstake, IL Bergval, AR Schuitema… - BMC infectious …, 2017 - Springer
… As PZA is part of current and planned MDR-TB treatment regimens this is alarming and …
Based on our typing and sequence analysis results we conclude that PZA resistance is the result …

[HTML][HTML] Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2 …

…, D Haj Slimene, N Sikhayeva, S Sengstake… - BMC Infectious …, 2019 - Springer
Background Kazakhstan remains a high-burden TB prevalence country with a concomitent
high-burden of multi-drug resistant tuberculosis. For this reason, we performed an in depth …

[HTML][HTML] Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates

S Sengstake, N Bablishvili, A Schuitema, N Bzekalava… - BMC genomics, 2014 - Springer
is especially interesting in areas where there is a high prevalence of multidrug resistant TB
(MDR-TB) and resistance is … , especially lineage identification, is almost always performed …

Mycobacterium tuberculosis genotypic drug resistance patterns and clustering in Jayapura, Papua, Indonesia

L Chaidir, S Sengstake, J De Beer… - … of Tuberculosis and …, 2015 - ingentaconnect.com
BACKGROUND: Little is known about drug-resistant tuberculosis (TB) and its transmission
in Papua, which has one of the highest rates of TB in Indonesia.DESIGN: We examined …

[HTML][HTML] The M25 gene products are critical for the cytopathic effect of mouse cytomegalovirus

I Kutle, S Sengstake, C Templin, M Glaß, T Kubsch… - Scientific reports, 2017 - nature.com
… , is characterized by typical rounding and enlargement of infected cells 6 . In fact, the latter
aspect is so characteristic that the virus received its name based on this property. HCMV is the …

Predominance of modern Mycobacterium tuberculosis strains and active transmission of Beijing sublineage in Jayapura, Indonesia Papua

L Chaidir, S Sengstake, J de Beer, A Oktavian… - Infection, Genetics and …, 2016 - Elsevier
Mycobacterium tuberculosis genotype distribution is different between West and Central
Indonesia, but there are no data on the most Eastern part, Papua. We aimed to identify the …