We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…

Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid
leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is …

Activating mutations of the FLT3 gene occur because of an internal tandem duplication of
the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain (FLT3/…

Purpose To improve survival rates in children with acute myeloid leukemia (AML), we evaluated
gemtuzumab-ozogamicin (GO), a humanized immunoconjugate targeted against CD33, …

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% …

CCG-2961 incorporated 3 new agents, idarubicin, fludarabine and interleukin-2, into a
phase 3 AML trial using intensive-timing remission induction/consolidation and related donor …

Early response to induction chemotherapy is a predictor of outcome in acute myeloid leukemia
(AML). We determined the prevalence and significance of postinduction residual disease (…

… Primary data analyses were performed by Dr Alonzo and Mr Gerbing, CCG statisticians. The
interpretation of the data was the primary responsibility of these 2 statisticians and Dr Lange…

… Alonzo and Pepe38 provide analytic expressions for estimates of prevalence, sensitivity …
Alonzo and Pepe38 show that when test results are positively correlated for infected and=or …

Receiver operating characteristic (ROC) regression methodology is used to identify factors
that affect the accuracy of medical diagnostic tests. In this paper, we consider a ROC model …