We have tested the specificity and utility of more than 200 antibodies raised against 57 different
histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human …

Genome function is dynamically regulated in part by chromatin, which consists of the histones,
non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis …

Chromatin immunoprecipitation identifies specific interactions between genomic DNA and
proteins, advancing our understanding of gene-level and chromosome-level regulation. …

Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases.
Set2-related H3K36 methyltransferases are targeted to genes by association with RNA …

Background Although Caenorhabditis elegans was the first multicellular organism with a
completely sequenced genome, how this genome is arranged within the nucleus is not known. …

The mechanisms that control cell growth during the cell cycle are poorly understood. In
budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton …

The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline.
MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and generate …

Specialized ribonucleoprotein organelles collectively known as germ granules are found in
the germline cytoplasm from worms to humans [1]. In Drosophila, germ granules have been …

RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis elegans.
The initial 5′ end of most protein-coding transcripts is removed by trans-splicing, and …

Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During
translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step …