User profiles for T. C. Mathers

Thomas Charles Mathers

Senior Computer Biologist, Wellcome Sanger Institute
Verified email at sanger.ac.uk
Cited by 859

[HTML][HTML] Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species

TC Mathers, Y Chen, G Kaithakottil, F Legeai… - Genome biology, 2017 - Springer
Background The prevailing paradigm of host-parasite evolution is that arms races lead to
increasing specialisation via genetic adaptation. Insect herbivores are no exception and the …

Evolutionary genomics of anthroponosis in Cryptosporidium

JL Nader, TC Mathers, BJ Ward, JA Pachebat… - Nature …, 2019 - nature.com
Human cryptosporidiosis is the leading protozoan cause of diarrhoeal mortality worldwide,
and a preponderance of infections is caused by Cryptosporidium hominis and C. parvum. …

Chromosome-scale genome assemblies of aphids reveal extensively rearranged autosomes and long-term conservation of the X chromosome

TC Mathers, RHM Wouters, ST Mugford… - Molecular Biology …, 2021 - academic.oup.com
Chromosome rearrangements are arguably the most dramatic type of mutations, often
leading to rapid evolution and speciation. However, chromosome dynamics have only been …

An aphid RNA transcript migrates systemically within plants and is a virulence factor

…, A Singh, GG Kaithakottil, TC Mathers… - Proceedings of the …, 2020 - National Acad Sciences
Aphids are sap-feeding insects that colonize a broad range of plant species and often
cause feeding damage and transmit plant pathogens, including bacteria, viruses, and viroids. …

[HTML][HTML] Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzuspersicae

…, BJ Troczka, A Pym, J Mackisack, TC Mathers… - Communications …, 2021 - nature.com
The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional
ability to develop resistance to both natural and synthetic insecticides. To investigate the …

A chromosome‐level genome assembly of the woolly apple aphid, Eriosoma lanigerum Hausmann (Hemiptera: Aphididae)

…, G Powell, SA Hogenhout, TC Mathers - Molecular ecology …, 2021 - Wiley Online Library
Woolly apple aphid (WAA, Eriosoma lanigerum Hausmann) (Hemiptera: Aphididae) is a
major pest of apple trees (Malus domestica, order Rosales) and is critical to the economics of …

Sex‐specific changes in the aphid DNA methylation landscape

TC Mathers, ST Mugford, L Percival‐Alwyn… - Molecular …, 2019 - Wiley Online Library
Aphids present an ideal system to study epigenetics as they can produce diverse, but
genetically identical, morphs in response to environmental stimuli. Here, using whole genome …

Genomic erosion in a demographically recovered bird species during conservation rescue

…, L Venturi, HE Morales, TC Mathers… - Conservation …, 2022 - Wiley Online Library
The pink pigeon (Nesoenas mayeri) is an endemic species of Mauritius that has made a
remarkable recovery after a severe population bottleneck in the 1970s to early 1990s. Prior to …

[HTML][HTML] Multiple global radiations in tadpole shrimps challenge the concept of 'living fossils'

TC Mathers, RL Hammond, RA Jenner, B Hänfling… - PeerJ, 2013 - peerj.com
‘Living fossils’, a phrase first coined by Darwin, are defined as species with limited recent
diversification and high morphological stasis over long periods of evolutionary time. …

Genome Sequence of the Banana Aphid, Pentalonia nigronervosa Coquerel (Hemiptera: Aphididae) and Its Symbionts

TC Mathers, ST Mugford, SA Hogenhout… - G3: Genes, Genomes …, 2020 - academic.oup.com
The banana aphid, Pentalonia nigronervosa Coquerel (Hemiptera: Aphididae), is a major
pest of cultivated bananas (Musa spp., order Zingiberales), primarily due to its role as a vector …