Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq)
has become a valuable and widely used approach for mapping the genomic location of …

Technologies that enable targeted manipulation of epigenetic marks could be used to
precisely control cell phenotype or interrogate the relationship between the epigenome and …

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes;
the ensemble of these binding events forms a regulatory network, constituting the wiring …

Technologies for engineering synthetic transcription factors have enabled many advances
in medical and scientific research. In contrast to existing methods based on engineering of …

… five times with an LiCl wash buffer (100 mM Tris, pH 7.5, 500 mM LiCl, 1% NP-40, 1% sodium
deoxycholate), and remaining ions were removed with a single wash with 1 mL of TE (10 …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types, …

The third primary production algorithm round robin (PPARR3) compares output from 24 models
that estimate depth-integrated primary production from satellite measurements of ocean …

… the beads five times with a LiCl wash buffer (100 mM Tris at pH 7.5, 500 mM LiCl, 1% NP-40,
1% sodium deoxycholate) and removed remaining ions with a single wash with 1 mL of TE (…

The CRISPR/Cas9 genome-editing platform is a promising technology to correct the genetic
basis of hereditary diseases. The versatility, efficiency and multiplexing capabilities of the …