Direct evidence for the requirement of transcriptional feedback repression in circadian clock
function has been elusive. Here, we developed a molecular genetic screen in mammalian …

How global organ asymmetry and individual cell polarity are connected to each other is a
central question in studying planar cell polarity (PCP). In the Drosophila wing, which develops …

Singularity behaviour in circadian clocks 1 , 2 — the loss of robust circadian rhythms following
exposure to a stimulus such as a pulse of bright light — is one of the fundamental but …

Sparked by the development of genome sequencing technology, the quantity and quality of
data handled in immunological research have been changing dramatically. Various data and …

During embryogenesis, cells repeatedly divide and dynamically change their positions in
three-dimensional (3D) space. A robust and accurate algorithm to acquire the 3D positions of …

Condensin I is a five-subunit protein complex that plays a central role in mitotic chromosome
assembly and segregation in eukaryotes. To dissect its mechanism of action, we …

Decision making in a noisy and dynamically changing environment is a fundamental task for
a cell. To choose appropriate decisions over time, a cell must be equipped with intracellular …

The theory of chemical kinetics forms the basis to describe the dynamics of chemical reaction
networks. Owing to physical and thermodynamic constraints, the networks possess various …

We derive the Hessian geometric structure of nonequilibrium chemical reaction networks on
the flux and force spaces induced by the Legendre duality of convex dissipation functions …

Stochasticity is an intrinsic property of genetic regulatory networks due to the low copy numbers
of the major molecular species, such as, DNA, mRNA, and regulatory proteins. Therefore…