… h | Single-cell transcriptome sequencing enables the identification of distinct populations of
infiltrating T … work in model systems further illuminating the biology of T cell exhaustion 207 . …

… T Cell High Tumors Are Associated with an Increased Abundance of PD-1+ … T Cells We
hypothesized that T cell high tumors possess distinct cellular and molecular features relative to T …

… Statistical tests for the enrichment of event types were based on t-sample t-tests for significance.
For analysis of the level of heterogeneity/homogeneity of deletions and gains, FACETS …

Copy number variation (CNV) is increasingly recognized as an important contributor to
phenotypic variation in health and disease. Most methods for determining CNV rely on …

Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor
growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent …

There are still gaps in our understanding of the complex processes by which p53 suppresses
tumorigenesis. Here we describe a novel role for p53 in suppressing the mevalonate …

… d, RNA-seq comparison of chromosome 11 gene-expression levels between the 11B3 Δ /Trp53
Δ and T r p 5 3 Δ / Δ leukaemia generated in b (n = 4). e, Gene set enrichment analysis …

We present Ginkgo ( http://qb.cshl.edu/ginkgo ), a user-friendly, open-source web platform for
the analysis of single-cell copy-number variations (CNVs). Ginkgo automatically constructs …

Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile
preclinical models that mimic the natural stages of CRC progression are lacking. Through the …

… Mechanistically, IFN co-deletion disrupted type I IFN signaling in the tumor microenvironment,
leading to marked changes in infiltrating immune cells and escape from CD8 + T-cell …