… cytotoxic T cells (68). Moreover, dense tumor stroma prevents T cell penetration while
immunosuppressive factors released by tumor cells, suppressor T cells and TAMs can cause T cell …

… In terms of adaptive immunity, T helper 1 (Th1) and T helper 17 (Th17) cells are the main
T lymphocytes required for anti-Candida albicans responses (355, 356). Interestingly, C. …

Reliable orthology prediction is central to comparative genomics. Although orthology is
defined by phylogenetic criteria, most automated prediction methods are based on pairwise …

… Garcia-Gomez and members of the Gabaldón group for fruitful discussions and suggestions.
The authors also thank Jordi Burguet-Castell, Pablo Escobar and Joaquín Tàrraga for their …

With the increasing availability of various ‘omics data, high-quality orthology assignment is
crucial for evolutionary and functional genomics studies. We here present the fourth version …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

Synonymous mutations change the sequence of a gene without directly altering the sequence
of the encoded protein. Here, we present evidence that these "silent" mutations frequently …

… Recently, a thaumatin found in the beetle T. castaneum was shown to inhibit spore germination
of the filamentous fungi Beauveria bassiana and Fusarium culmorum [32]. Phylogenetic …

Many genomes display high levels of heterozygosity (ie presence of different alleles at the
same loci in homologous chromosomes), being those of hybrid organisms an extreme such …

… cerevisiae, all the species belonging to the ZT and KLE clades (T. delbrueckii, Z. rouxii, …
The authors wish to thank members of the Gabaldon group for discussions and Bernard Dujon …