Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …

… Further analysis of lymphocyte subpopulations was restricted to total T cells, CD4 and CD8
T cells, as well as natural killer (NK) cells. Most patients have normal T-cell numbers (1204 ± …

Counting individual RNA or DNA molecules is difficult because they are hard to copy
quantitatively for detection. To overcome this limitation, we applied unique molecular identifiers (…

INTRODUCTION Nearly all cells in the human body share the same primary genome sequence
consisting of four nucleotide bases. One of the bases, cytosine, is commonly modified by …

Members of the large ETS family of transcription factors (TFs) have highly similar DNA‐binding
domains (DBDs)—yet they have diverse functions and activities in physiology and …

The genetic code—the binding specificity of all transfer-RNAs—defines how protein primary
structure is determined by DNA sequence. DNA also dictates when and where proteins are …

… We found that the observed rate of A•T>C•G and A•T>G•C substitutions was significantly
higher than the expected rate (Supplementary Fig. 4 and Supplementary Table 3). Whereas in …

… functions as cofactor for transcription factors of the TCF (T-cell factor)/LEF (lymphoid enhancer
… We did not examine whether the imbalance is due to loss of the nonrisk T allele or gain of …

Gene expression is regulated by transcription factors (TFs), proteins that recognize short DNA
sequence motifs 1 , 2 , 3 . Such sequences are very common in the human genome, and …

During cell division, transcription factors (TFs) are removed from chromatin twice, during
DNA synthesis and during condensation of chromosomes. How TFs can efficiently find their …