INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

Successful commercialization is of great importance to innovative firms, and the recent literature
has increasingly acknowledged that networks make a contribution not only to research …

Complex traits, including migraine, often aggregate in families, but the underlying genetic
architecture behind this is not well understood. The aggregation could be explained by rare, …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

We tested the hypothesis that de novo copy number variation (CNV) is associated with autism
spectrum disorders (ASDs). We performed comparative genomic hybridization (CGH) on …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …

… Terho Lehtimäki reports no disclosures. Ruth McPherson has served on the editorial board
of Arteriosclerosis, Thrombosis & Vascular Biology; and has received research support from …