Balance of activity during a critical period tunes a developing network

I Hunter, B Coulson, T Pettini, JJ Davies, J Parkin… - Elife, 2024 - elifesciences.org
Developing neural circuits are influenced by activity and are especially sensitive to changes
in activity during critical periods (CPs) of development. Changes occurring during a CP …

Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

NE Phillips, CS Manning, T Pettini, V Biga… - Elife, 2016 - elifesciences.org
… where Pšn;tŽ is the probability of finding the system in state n at time t, and Pšn;t;n0;t0Ž is
the probability for the system to be in state n at t and in state n0 at time t0. Em, Ep and Er are …

[HTML][HTML] smiFISH and embryo segmentation for single-cell multi-gene RNA quantification in arthropods

L Calvo, M Ronshaugen, T Pettini - Communications Biology, 2021 - nature.com
Recently, advances in fluorescent in-situ hybridization techniques and in imaging technology
have enabled visualization and counting of individual RNA molecules in single cells. This …

Electrophysiological validation of monosynaptic connectivity between premotor interneurons and the aCC motoneuron in the Drosophila larval CNS

CNG Giachello, I Hunter, T Pettini… - Journal of …, 2022 - Soc Neuroscience
The Drosophila connectome project aims to map the synaptic connectivity of entire larval
and adult fly neural networks, which is essential for understanding nervous system …

Visualizing gene expression during zebrafish pronephros development and regeneration

…, HM Wesselman, EE Morales, N Handa, T Pettini… - Methods in cell …, 2019 - Elsevier
The vertebrate kidney is comprised of functional units known as nephrons. Defects in
nephron development or activity are a common feature of kidney disease. Current medical …

[HTML][HTML] The embryonic transcriptome of Parhyale hawaiensis reveals different dynamics of microRNAs and mRNAs during the maternal-zygotic transition

L Calvo, M Birgaoanu, T Pettini, M Ronshaugen… - Scientific Reports, 2022 - nature.com
Parhyale hawaiensis has emerged as the crustacean model of choice due to its tractability,
ease of imaging, sequenced genome, and development of CRISPR/Cas9 genome editing …

Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER+ breast cancer cells

…, E Marinopoulou, T Pettini… - Proceedings of the …, 2021 - National Acad Sciences
Here, we study the dynamical expression of endogenously labeled Hes1, a transcriptional
repressor implicated in controlling cell proliferation, to understand how cell-cycle length …

Geometrical hints for a nonperturbative approach to Hamiltonian dynamics

M Pettini - Physical Review E, 1993 - APS
… In fact a SST is found at the critical temperature T„at which the system undergoes a Kosterlitz…
of the arc length is affine we can replace s with t in ordinary and covariant derivatives. Finally…

[HTML][HTML] CD4+ T cell priming as biomarker to study immune response to preventive vaccines

A Ciabattini, E Pettini, D Medaglini - Frontiers in immunology, 2013 - frontiersin.org
… -specific T cells. This review discusses the current knowledge on antigen-specific CD4 + T
… the in vivo T cell priming and the opportunities offered by the application of systems biology. …

[HTML][HTML] Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice

A Ciabattini, E Pettini, F Fiorino, G Prota, G Pozzi… - PloS one, 2011 - journals.plos.org
Priming of T cells is a key event in vaccination, since it bears a decisive influence on the type
and magnitude of the immune response. T-cell priming after mucosal immunization via the …