An algorithm for the assignment of phosphorylation sites in peptides is described. The
program uses tandem mass spectrometry data in conjunction with the respective peptide …

… ion tolerance t, considering … t (2)probability p is defined as (3) The overlap O(F(s,pep,m))
is the sum of all overlapping ranges in the theoretical spectrum F considering mass tolerance t. …

Peptide labeling with isobaric tags has become a popular technique in quantitative shotgun
proteomics. Using two different samples viz. a protein mixture and HeLa extracts, we show …

The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

We recently introduced a novel scheme combining electron-transfer and higher-energy
collision dissociation (termed EThcD), for improved peptide ion fragmentation and identification. …

… We consider unlinked biallelic loci with alleles A and a that evolve at a constant population
size N e for t nonoverlapping generations. Relative fitness is given by w A =1 + s and w a =1 …

… Additionally, we take into account variable coverage levels across the genome (coverage
Rij for site i at T=j, j∈{0,t}) when correcting for the variance coming from sequencing. …

Quality control is increasingly recognized as a crucial aspect of mass spectrometry based
proteomics. Several recent papers discuss relevant parameters for quality control and present …

… We therefore estimate the distribution of T * by simulating uniformly distributed p-values
under the global null. Note, however, that some of our considered transformations lead to …

Meiotic recombination is crucial for chromosomal segregation and facilitates the spread of
beneficial and removal of deleterious mutations. Recombination rates frequently vary along …