[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

…, PR Loh, G Bhatia, R Do, T Hayeck… - The american journal of …, 2015 - cell.com
… In addition, we removed SNPs that had ambiguous nucleotides, ie, A/T and G/C. We matched
the SNPs between the validation and GWAS summary-statistics datasets on the basis of …

Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans.

…, N Volkova, D Presser, J Attias, T Hayek… - … and clinical Research, 2002 - europepmc.org
The beneficial health effects attributed to the consumption of fruit and vegetables are related,
at least in part, to their antioxidant activity. Of special interest is the inverse relationship …

The prevalence of Barrett's esophagus in the US: estimates from a simulation model confirmed by SEER data

TJ Hayeck, CY Kong, SJ Spechler… - Diseases of the …, 2010 - academic.oup.com
Barrett’s esophagus (BE) is the precursor and the biggest risk factor for esophageal
adenocarcinoma (EAC), the solid cancer with the fastest rising incidence in the US and western …

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

AS Plump, JD Smith, T Hayek, K Aalto-Setälä, A Walsh… - Cell, 1992 - cell.com
… In these 5 mice, mean lesion area per section per animal was found to be 9230 _ 4700 t~m
2 (Figure 5). Two of the fourteen controls were analyzed by qualitative histological techniques…

A mouse model for human atherosclerosis: long-term histopathological study of lesion development in the aortic arch of apolipoprotein E-deficient (E0) mice

R Coleman, T Hayek, S Keidar, M Aviram - Acta histochemica, 2006 - Elsevier
… Cholesterol deposits are seen in the Tunica intima and extend into the T. media. Resin … (c)
Infiltrating cells similar in appearance to chondrocytes are seen in lacunae in the T. media. (d–f…

[HTML][HTML] Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in …

…, N Volkova, M Kaplan, R Coleman, T Hayek… - The American journal of …, 2000 - Elsevier
… Student’s paired t tests were performed for all statistical analyses. Results are given as
means ± SDs. The degree of variation between experiments ranged from 7% to 9%. …

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL …

…, N Volkova, D Presser, J Attias, H Liker, T Hayek - Clinical nutrition, 2004 - Elsevier
Dietary supplementation with polyphenolic antioxidants to animals was shown to be associated
with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of …

Reduced progression of atherosclerosis in apolipoprotein E–deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated …

T Hayek, B Fuhrman, J Vaya, M Rosenblat… - … , and vascular biology, 1997 - Am Heart Assoc
The effect of consuming red wine, or its major polyphenol constituents catechin or quercetin,
on the development of atherosclerotic lesions, in relation to the susceptibility of plasma LDL …

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated …

…, X Chen, T Chajek-Shaul, T Hayek… - The Journal of …, 1992 - Am Soc Clin Investig
Hypertriglyceridemia is common in the general population, but its mechanism is largely
unknown. In previous work human apo CIII transgenic (HuCIIITg) mice were found to have …

[PDF][PDF] Mixed model with correction for case-control ascertainment increases association power

TJ Hayeck, NA Zaitlen, PR Loh, B Vilhjalmsson… - The American Journal of …, 2015 - cell.com
… An individual is affected by a disease if the liability exceeds a specified threshold (t), …
above or below, respectively, the liability threshold t.We next consider the multivariate PML (…