The fetal-to-adult hemoglobin switch and silencing of fetal hemoglobin (HbF) have been areas
of long-standing interest among hematologists, given the fact that clinical induction of HbF …

Anemia is a major source of morbidity and mortality worldwide. Here we review recent insights
into how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying …

The study of haemoglobin switching has represented a focus in haematology due in large
part to the clinical relevance of the fetal to adult haemoglobin switch for developing targeted …

The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

… Sankaran for assistance with data analysis. This work was supported by grants from the
National Heart, Lung, and Blood Institute, NIH (HL32262-26 and HL32259-27), a Center of …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

β-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity,
despite being generally thought of as simple Mendelian diseases. The reasons for this are …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we …

Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable
phenotype characterized by severe pain crises, acute clinical events, and early mortality. …

The contribution of changes in cis-regulatory elements or trans-acting factors to interspecies
differences in gene expression is not well understood. The mammalian β-globin loci have …