Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and spatially …

Multiplexed imaging enables the simultaneous spatial profiling of dozens of biological molecules
in tissues at single-cell resolution. Extracting biologically relevant information, such as …

A defining hallmark of cancer and cancer development is upregulated angiogenesis. The
vasculature formed in tumors is structurally abnormal, not organized in the conventional …

The data-independent acquisition (DIA) approach has recently been introduced as a novel
mass spectrometric method that promises to combine the high content aspect of shotgun …

Immune cells in the tumor microenvironment modulate cancer progression and are attractive
therapeutic targets. Macrophages and T cells are key components of the microenvironment, …

Single-cell analyses have revealed extensive heterogeneity between and within human
tumours 1 , 2 , 3 – 4 , but complex single-cell phenotypes and their spatial context are not at …

Single-cell, spatially resolved omics analysis of tissues is poised to transform biomedical
research and clinical practice. We have developed an open-source, computational histology …

The functions of the tumor microenvironment (TME) are orchestrated by precise spatial
organization of specialized cells, yet little is known about the multicellular structures that form …

Tumor microvasculature tends to be malformed, more permeable, and more tortuous than
vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF …

The advent of mass cytometry increased the number of parameters measured at the single-cell
level while decreasing the extent of crosstalk between channels relative to dye-based …